MK-886
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Preferred IUPAC name 3-{3-(tert-Butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl}-2,2-dimethylpropanoic acid | |
Other names L-663536 | |
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3D model (JSmol) |
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MeSH | L+663536 |
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Properties | |
Chemical formula | C27H34ClNO2S |
Molar mass | 472.083 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references |
Chemical compound
MK-886, or L-663536, is a leukotriene antagonist. It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX),[1] and may help in treating atherosclerosis.[2]
References
- ^ Jun, Joon-Il; Lau, Lester F. (July 2010). "The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing". Nature Cell Biology. 12 (7): 676–685. doi:10.1038/ncb2070. ISSN 1465-7392. PMC 2919364. PMID 20526329.
- ^ Jawien, J.; Gajda, M.; Rudling, M.; Mateuszuk, L.; Olszanecki, R.; Guzik, T. J.; Cichocki, T.; Chlopicki, S.; Korbut, R. (March 2006). "Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice". European Journal of Clinical Investigation. 36 (3): 141–146. doi:10.1111/j.1365-2362.2006.01606.x. PMID 16506957. S2CID 44897529.
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Leukotriene signaling modulators
(ligands)
BLTTooltip Leukotriene B4 receptor |
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CysLTTooltip Cysteinyl leukotriene receptor |
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(inhibitors)
5-LOXTooltip Arachidonate 5-lipoxygenase |
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12-LOXTooltip Arachidonate 12-lipoxygenase |
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15-LOXTooltip Arachidonate 15-lipoxygenase |
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LTA4HTooltip Leukotriene A4 hydrolase |
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LTB4HTooltip Leukotriene B4 ω-hydroxylase |
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LTC4STooltip Leukotriene C4 synthase |
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LTC4HTooltip Leukotriene C4 hydrolase |
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LTD4Tooltip Leukotriene D4 hydrolase |
- See also
- Receptor/signaling modulators
- Prostanoid signaling modulators
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