MicroRNA 93

Non-coding RNA in the species Homo sapiens

MIR93

Identifiers

Aliases

MIR93, MIRN9, MIRN93, hsa-mir-93, miR-93, microRNA 93

External IDs

OMIM: 612984; GeneCards: MIR93; OMA:MIR93 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q22.1	Start	100,093,768 bp^[1]
Band	7q22.1	End	100,093,847 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bone marrow

skeletal muscle tissue

granulocyte

endometrium

gonad

sural nerve

blood

rectum

lymph node

placenta

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


407050


n/a

Ensembl


ENSG00000207757


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 7: 100.09 – 100.09 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene. ^[3]

Function

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nucleotide long stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target messenger RNAs (mRNA) through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000207757 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MicroRNA 93". Retrieved 2018-10-24.
^ RefSeq, Sep 2009

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Roccaro AM, Sacco A, Jia X, Azab AK, Maiso P, Ngo HT, Azab F, Runnels J, Quang P, Ghobrial IM (September 2010). "microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia". Blood. 116 (9): 1506–14. doi:10.1182/blood-2010-01-265686. PMC 2938840. PMID 20519629.
Hu Z, Shu Y, Chen Y, Chen J, Dong J, Liu Y, Pan S, Xu L, Xu J, Wang Y, Dai J, Ma H, Jin G, Shen H (March 2011). "Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival". Am. J. Respir. Crit. Care Med. 183 (5): 641–8. doi:10.1164/rccm.201005-0717OC. PMID 20889907.
Fang L, Deng Z, Shatseva T, Yang J, Peng C, Du WW, Yee AJ, Ang LC, He C, Shan SW, Yang BB (February 2011). "MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8". Oncogene. 30 (7): 806–21. doi:10.1038/onc.2010.465. PMID 20956944.
Choi OR, Lim IK (April 2011). "Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter". Biochem. Biophys. Res. Commun. 407 (2): 406–11. doi:10.1016/j.bbrc.2011.03.038. PMID 21402054.