SERPINB9

Protein-coding gene in the species Homo sapiens
SERPINB9
Identifiers
AliasesSERPINB9, CAP-3, CAP3, PI-9, PI9, serpin family B member 9
External IDsOMIM: 601799; MGI: 106603; HomoloGene: 37888; GeneCards: SERPINB9; OMA:SERPINB9 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SERPINB9
Genomic location for SERPINB9
Band6p25.2Start2,887,270 bp[1]
End2,903,309 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for SERPINB9
Genomic location for SERPINB9
Band13 A3.2- A3.3|13 13.79 cMStart33,187,233 bp[2]
End33,201,940 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of nasopharynx

  • mononuclear cell

  • monocyte

  • germinal epithelium

  • appendix

  • lymph node

  • placenta

  • tibial nerve

  • blood

  • granulocyte
Top expressed in
  • right lung lobe

  • gastrula

  • left lung

  • mesenteric lymph nodes

  • left lung lobe

  • placenta

  • lumbar spinal ganglion

  • Epithelium of choroid plexus

  • carotid body

  • spleen
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • peptidase inhibitor activity
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process
  • protease binding
  • protein binding
  • serine-type endopeptidase inhibitor activity
Cellular component
  • cytosol
  • membrane
  • intracellular anatomical structure
  • extracellular exosome
  • nucleus
  • cytoplasm
  • extracellular space
  • nucleoplasm
  • Golgi apparatus
  • collagen-containing extracellular matrix
Biological process
  • negative regulation of peptidase activity
  • mast cell mediated immunity
  • negative regulation of apoptotic process
  • protection from natural killer cell mediated cytotoxicity
  • cellular response to estrogen stimulus
  • positive regulation of gene expression
  • negative regulation by symbiont of host apoptotic process
  • immune response
  • negative regulation of endopeptidase activity
  • apoptotic process
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5272

20723

Ensembl

ENSG00000170542

ENSMUSG00000045827

UniProt

P50453

O08797

RefSeq (mRNA)

NM_004155

NM_009256

RefSeq (protein)

NP_004146
NP_004146.1

NP_033282

Location (UCSC)Chr 6: 2.89 – 2.9 MbChr 13: 33.19 – 33.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene.[5][6][7] PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170542 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045827 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
  6. ^ Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835. S2CID 23659776.
  7. ^ a b "Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9".

Further reading

  • Sun J, Bird CH, Sutton V, et al. (1996). "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9. doi:10.1074/jbc.271.44.27802. PMID 8910377.
  • Annand RR, Dahlen JR, Sprecher CA, et al. (1999). "Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9". Biochem. J. 342 Pt 3 (3): 655–65. doi:10.1042/0264-6021:3420655. PMC 1220507. PMID 10477277.
  • Kanamori H, Krieg S, Mao C, et al. (2000). "Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells". J. Biol. Chem. 275 (8): 5867–73. doi:10.1074/jbc.275.8.5867. PMID 10681578.
  • Bladergroen BA, Strik MC, Bovenschen N, et al. (2001). "The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites". J. Immunol. 166 (5): 3218–25. doi:10.4049/jimmunol.166.5.3218. PMID 11207275.
  • Buzza MS, Hirst CE, Bird CH, et al. (2001). "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses". Cell. Immunol. 210 (1): 21–9. doi:10.1006/cimm.2001.1806. PMID 11485349.
  • Hirst CE, Buzza MS, Sutton VR, et al. (2002). "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction". Mol. Hum. Reprod. 7 (12): 1133–42. doi:10.1093/molehr/7.12.1133. PMID 11719590.
  • Tanaka K, Harashima N, Niiya F, et al. (2002). "Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients". Jpn. J. Cancer Res. 93 (2): 198–208. doi:10.1111/j.1349-7006.2002.tb01259.x. PMC 5926951. PMID 11856484.
  • ten Berge RL, Meijer CJ, Dukers DF, et al. (2002). "Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma". Blood. 99 (12): 4540–6. doi:10.1182/blood.V99.12.4540. PMID 12036886.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hirst CE, Buzza MS, Bird CH, et al. (2003). "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency". J. Immunol. 170 (2): 805–15. doi:10.4049/jimmunol.170.2.805. PMID 12517944.
  • Rowshani AT, Florquin S, Bemelman F, et al. (2005). "Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection". Kidney Int. 66 (4): 1417–22. doi:10.1111/j.1523-1755.2004.00903.x. PMID 15458434.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B". J. Biol. Chem. 279 (52): 54275–82. doi:10.1074/jbc.M411482200. PMID 15494398.
  • Classen CF, Ushmorov A, Bird P, Debatin KM (2006). "The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias". Haematologica. 89 (11): 1314–21. PMID 15531453.
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
  • van Houdt IS, Oudejans JJ, van den Eertwegh AJ, et al. (2005). "Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma". Clin. Cancer Res. 11 (17): 6400–7. doi:10.1158/1078-0432.CCR-05-0306. PMID 16144945.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

  • The MEROPS online database for peptidases and their inhibitors: I04.014
  • SERPINB9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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