MELK

Struktur yang tersedia

PDB

Pencarian Ortolog: PDBe RCSB

Daftar kode id PDB
4BKY, 4BKZ, 4D2P, 4D2T, 4D2V, 4D2W, 4IXP, 4UMP, 4UMQ, 4UMR, 4UMT, 4UMU, 5IHA, 5IHC, 5IH9, 5IH8

Pengidentifikasi

Alias

MELK, HPK38, maternal embryonic leucine zipper kinase

ID eksternal

OMIM: 607025 MGI: 106924 HomoloGene: 32111 GeneCards: MELK

EC number

2.7.10.2

Pola ekspresi RNA

Referensi data ekspresi selengkapnya

Ontologi gen
Fungsi molekuler	• transferase activity • nucleotide binding • calcium ion binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 Ikatan protein plasma • ATP binding • lipid binding
Komponen seluler	• sitoplasma • membran • Membran sel • cell cortex • Inti sel
Proses biologis	• intrinsic apoptotic signaling pathway in response to oxidative stress • hematapoises • GO:0007243 intracellular signal transduction • Fosforilasi • protein phosphorylation • G2/M transition of mitotic cell cycle • neural precursor cell proliferation • positive regulation of apoptotic process • protein autophosphorylation • Siklus sel • cell population proliferation • GO:0097285 Apoptosis • peptidyl-tyrosine phosphorylation
Sumber:Amigo / QuickGO

Ortolog

Spesies

Manusia

Tikus

Entrez


9833


17279

Ensembl


ENSG00000165304


ENSMUSG00000035683

UniProt


Q14680


Q61846

RefSeq (mRNA)

NM_001256685 NM_001256687 NM_001256688 NM_001256689 NM_001256690
NM_001256691 NM_001256692 NM_001256693 NM_014791


NM_010790

RefSeq (protein)

NP_001243614 NP_001243616 NP_001243617 NP_001243618 NP_001243619
NP_001243620 NP_001243621 NP_001243622 NP_055606


NP_034920

Lokasi (UCSC)

n/a

Pencarian PubMed

^[1]

^[2]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Maternal embryonic leucine zipper kinase (MELK) adalah enzim yang pada manusia disandi oleh gen MELK.^[3]^[4]^[5] MELK adalah serin/treonin kinase milik keluarga protein AMPK/snf1 kinase. MELK pertama kali diidentifikasi hadir sebagai mRNA maternal pada embrio tikus.^[6] MELK telah terbukti terlibat dalam perkembangan melalui siklus sel, mungkin terkait dengan interaksinya dengan CDC25B.^[7]

Ekspresi MELK meningkat pada sejumlah kanker dan merupakan target penelitian aktif untuk penghambatan farmakologis.^[8]

Interaksi

MELK telah terbukti berinteraksi dengan CDC25B.^[9]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. February 1996. doi:10.1093/dnares/3.1.17. PMID 8724849.
^ "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. June 1997. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
^ "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. August 1999. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823.
^ "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. August 2005. doi:10.1083/jcb.200412115. PMC 2171475 . PMID 16061694.
^ "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. November 2005. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996.
^ "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. October 2002. doi:10.1038/sj.onc.1205870. PMID 12400006.