Neuromedinski B receptor

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Neuromedinski B receptor
Identifikatori
SimboliNMBR;
Vanjski IDOMIM: 162341 MGI: 1100525 HomoloGene: 20560 IUPHAR: BB1 GeneCards: NMBR Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost bombesinskog receptora
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • prenos signala
• G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C)
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez482918101
EnsemblENSG00000135577ENSMUSG00000019865
UniProtP28336Q0VEH1
RefSeq (mRNA)NM_002511NM_008703
RefSeq (protein)NP_002502NP_032729
Lokacija (UCSC)Chr 6:
142.44 - 142.45 Mb		Chr 10:
14.45 - 14.46 Mb
PubMed pretraga[1][2]

Neuromedinski B receptor (NMBR), takođe poznat kao BB1 [1] je G protein-spregnuti receptor čiji je endogeni ligand neuromedin B[2].

Neuromedinski B receptor vezuje neuromedin B, potentni mitogen i faktor rasta za normalno i neoplastično tkivo pluća i gastrointestinalnog epitela.[3]

Literatura

  1. ↑ „Bombesin Receptors: BB1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2013-10-04. 
  2. ↑ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). „Expression and characterization of cloned human bombesin receptors”. Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. Arhivirano iz originala na datum 2008-09-06. Pristupljeno 2014-05-08. 
  3. ↑ „Entrez Gene: NMBR neuromedin B receptor”. 

Dodatna literatura

  • Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). „Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.”. J. Biol. Chem. 266 (28): 18771–9. PMID 1655761. 
  • Wu JM, Hoang DO, Feldman RI (1995). „Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs.”. Mol. Pharmacol. 47 (4): 871–81. PMID 7723750. 
  • Benya RV, Kusui T, Pradhan TK, et al. (1995). „Expression and characterization of cloned human bombesin receptors.”. Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  • Bitar KN, Zhu XX (1994). „Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction.”. Gastroenterology 105 (6): 1672–80. PMID 8253343. 
  • Giladi E, Nagalla SR, Spindel ER (1993). „Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.”. J. Mol. Neurosci. 4 (1): 41–54. DOI:10.1007/BF02736689. PMID 8391296. 
  • Fathi Z, Benya RV, Shapira H, et al. (1993). „The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding.”. J. Biol. Chem. 268 (20): 14622–6. PMID 8392057. 
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). „Bombesin-like peptide receptors in human bronchial epithelial cells.”. Peptides 17 (1): 111–8. DOI:10.1016/0196-9781(95)02088-8. PMID 8822519. 
  • Sainz E, Akeson M, Mantey SA, et al. (1998). „Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.”. J. Biol. Chem. 273 (26): 15927–32. DOI:10.1074/jbc.273.26.15927. PMID 9632639. 
  • Lee S, Kim Y (1999). „Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.”. FEBS Lett. 460 (2): 263–9. DOI:10.1016/S0014-5793(99)01346-0. PMID 10544247. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Matusiak D, Glover S, Nathaniel R, et al. (2005). „Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.”. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. DOI:10.1152/ajpgi.00156.2004. PMID 15528253. 

Spoljašnje veze

  • „Bombesin Receptors: BB1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2013-10-04. 
  • MeSH Receptors,+Bombesin
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)